Attributes of Hypoxic Preconditioning Determine the Complicating Atherogenesis of Plaques

Atherogenesis constitutes a prominent mechanism in inducing stenosis of the vascular lu‐ men by multiple mechanisms within contextual reference of heterogeneity of pathways and phenotype determinants. Reduction of low-density lipoprotein-C has well-established value and constitutes a major guideline for cardiovascular disease prevention [38]. Redox state im‐ balance plays a role in preclinical atherosclerosis [7]. The realization of events constituting the acute coronary syndromes is particularly critical in the evolution of lesions that further compromise blood supply to target tissues. It is highly significant to consider the distribu‐ tion of individual lesions with reference to disturbed blood flow patterns within the vascu‐ lar arterial tree, as further evidenced by selectivity to vascular branch points. Disturbed flow may hinder transport of nitric oxide particularly distal to a stenosis [17].